Hepatic acute-phase reaction in histamine-deficient gene targeted mice.

Abstract

Histamine is a versatile mediator that, according to in vitro studies, affects the synthesis of inflammatory cytokines and acute-phase proteins. The histidine-decarboxylase knockout (HDC-/-) mouse is a model of in vivo investigation of the physiologic and metabolic integration of the acutephase response. These mice do not synthesise histamine and feeding them with histamine-poor diet they are almost completely histamine-deficient. We compared the serum concentrations of representatives of acute-phase plasma proteins, as well as the levels IL-6 and IL-1alpha in wild type and HDC-/- mice during local (turpentine-induced) or systemic (LPS-induced) inflammation. The level of some acute-phase proteins significantly differed in wild-type and HDC-/- mice while others remained unaffected. The IL-6 levels are also differ in the wild-type and histamine-deficient animals, suggesting that the effect of histamine is attained through IL-6, although direct effect is not disclosed yet.

• Authors: A Donászi-Ivanov, P Scharek, A Falus, A K Fülöp
• Journal: Inflammopharmacology (Inflammopharmacology) Vol. 12 Issue 1 Pg. 47-55 ( 2004) ISSN: 0925-4692 [Print] Switzerland
• PMID: 15035778 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Acute-Phase Proteins
• Complement C3
• Interleukin-1
• Interleukin-6
• Serum Amyloid P-Component
• alpha-Macroglobulins
• Histamine
• Histidine Decarboxylase

Topics

• Acute-Phase Proteins (analysis)
• Animals
• Complement C3 (analysis)
• Histamine (physiology)
• Histidine Decarboxylase (deficiency, genetics)
• Interleukin-1 (blood)
• Interleukin-6 (blood)
• Male
• Mice
• Serum Amyloid P-Component (analysis)
• alpha-Macroglobulins (analysis)