| Abstract | BACKGROUND/AIMS: It is unknown whether the prokinetics improve the quality of life in patients with functional dyspepsia. Thus, we evaluate the effect of the mosapride, selective 5-HT4 agonist, on the symptom and life quality of patients with functional dyspepsia using the Nepean dyspepsia index-Korean version (NDI-K), a reliable and validated disease-specific quality of life questionnaire. METHODS: A single, open trial was performed in 129 patients with functional dyspepsia. Patients were received mosapride 5 mg t.i.d before each meal for 4 weeks. The symptoms and quality of life were measured with the NDI-K at baseline and 4 weeks. The responsiveness of the NDI-K was evaluated by correlation with symptom scores. RESULTS: All the 15 symptom scores and the dyspepsia score decreased after treatment (p<0.05). The total symptom score decreased from 60.9 +/- 25.8 to 24.7 +/- 20.4 (p=0.001). Correlations were observed between the total symptom score and the NDI-K score (r=0.47, p=0.001), and between the total symptom score and each score in 5 subscales (r=0.25-0.44, p=0.001). The NDI-K score was significantly increased in the effective group whose dyspepsia score decreased more than 50% of the score at baseline, compared with that of ineffective group. Any significant adverse effect and prolongation of QT interval were not occurred in all patients. CONCLUSIONS: A prokinetic drug, mosapride improves the symptoms and the quality of life in patients with functional dyspepsia. |
| Authors | Yu Kyung Cho, Myung-Gyu Choi, Se Hee Kim, In Seok Lee, Sang Woo Kim, In-Sik Chung, Sang Yeol Lee, Suck Chei Choi, Sang Young Seol
(Affiliation: Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seocho-gu, Seoul, Korea.)
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| Journal | The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
(Korean J Gastroenterol)
Vol. 43
Issue 3
Pg. 160-7
(Mar 2004)
ISSN: 1598-9992 Korea (South) |
| PMID | 15034286
(Publication Type: Clinical Trial, English Abstract, Journal Article)
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| Chemical References |
- Benzamides
- Dopamine Antagonists
- Gastrointestinal Agents
- Morpholines
- mosapride
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| Topics |
- Adult
- Aged
- Benzamides
(therapeutic use)
- Dopamine Antagonists
(therapeutic use)
- Dyspepsia
(diagnosis, drug therapy)
- Female
- Gastrointestinal Agents
(therapeutic use)
- Humans
- Male
- Middle Aged
- Morpholines
(therapeutic use)
- Quality of Life
- Questionnaires
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