Inhibitory effects of physalin B and physalin F on various human leukemia cells in vitro.

Abstract

Physalins B and F were isolated and characterized from the ethanolic extract of the whole plant of Physalis angulata L. (Solanaceae). Both physalin B and physalin F inhibited the growth of several human leukemia cells: K562 (erythroleukemia), APM1840 (acute T lymphoid leukemia), HL-60 (acute promyelocytic leukemia), KG-1 (acute myeloid leukemia), CTV1 (acute monocytic leukemia) and B cell (acute B lymphoid leukemia). Physalin F showed a stronger activity against these leukemia cells than physalin B, especially against acute myeloid leukemia (KG-1) and acute B lymphoid leukemia (B cell). From the structural features, the active site seems to be the functional epoxy group for physalin F and the double bond for physalin B located at carbon 5 and 6; the former is much more active than the latter as regards anti-leukemic effects.

• Authors: H C Chiang, S M Jaw, P M Chen
• Journal: Anticancer research (Anticancer Res) 1992 Jul-Aug Vol. 12 Issue 4 Pg. 1155-62 ISSN: 0250-7005 [Print] Greece
• PMID: 1503404 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Lactones
• Secosteroids
• Steroids
• physalin B
• physalin F

Topics

• Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
• Drug Screening Assays, Antitumor
• Humans
• Lactones (chemistry, pharmacology)
• Leukemia (drug therapy)
• Secosteroids
• Steroids
• Tumor Cells, Cultured