1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) induces apoptosis in human neuroblastoma cell lines.

Abstract	The former popular hypnotic chloral hydrate has been known to spontaneously condense with tryptamine in the body to give rise to a highly unpolar 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) derivative. Earlier studies have revealed the relative permeability of the molecule through the body, and its ability to induce Parkinson-like symptoms in rats. In this study, we report that TaClo is a highly cytotoxic agent that leads to apoptosis in human neuroblastoma cells involving caspase-3 activation.
Authors	Ravi Shankar Akundi, Michael Hüll, Hans Willi Clement, Bernd L Fiebich
Journal	Annals of the New York Academy of Sciences (Ann N Y Acad Sci) Vol. 1010 Pg. 304-6 (Dec 2003) ISSN: 0077-8923 [Print] United States
PMID	15033739 (Publication Type: Journal Article)
Chemical References	Carbolines 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline Caspases
Topics	Apoptosis (drug effects) Carbolines (chemical synthesis, pharmacology) Caspases (metabolism) Cell Line, Tumor Cell Membrane Permeability (drug effects) Humans Neuroblastoma

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