Effect of concanavalin A on lymphocyte interactions involved in the antibody response to type III pneumococcal polysaccharide I. Comparison of the suppression induced by con A and low dose paralysis.

Abstract

Concanavalin A (Con A) administered at the time of immunization induces suppression of the in vivo splenic plaque-forming cell (PFC) response to type III pneumococcal polysaccharide (SSS-III). As with low dose paralysis of the PFC response to SSS-III, Con A-induced suppression could not be demonstrated in congenitally athymic (nu/nu) mice and could be eliminated partially by treatment with anti-lymphocyte serum (ALS). The kinetics for Con A-induced suppression paralleled those for low dose paralysis of the antibody response to SSS-III. These findings support the view that Con A-induced suppression is produced in vivo by suppressor T cells and that this form of suppression shares with low dose paralysis a common pathway through which suppression is mediated.

• Authors: R B Markham, P W Stashak, B Prescott, D F Amsbaugh, P J Baker
• Journal: Journal of immunology (Baltimore, Md. : 1950) (J Immunol) Vol. 118 Issue 3 Pg. 952-6 (Mar 1977) ISSN: 0022-1767 [Print] United States
• PMID: 15032 (Publication Type: Journal Article)

Chemical References

• Polysaccharides, Bacterial
• Concanavalin A

Topics

• Animals
• Antibody Formation
• Concanavalin A (pharmacology)
• Dose-Response Relationship, Immunologic
• Female
• Hemolytic Plaque Technique
• Immunosuppression Therapy
• Mice
• Mice, Inbred BALB C
• Mice, Nude
• Polysaccharides, Bacterial (immunology)
• Streptococcus pneumoniae