Abstract |
Trivalent avian influenza (AIV) antigens (H4N8, H5N2 and H7N3), mixed with positively charged, negatively charged and neutral avridine-containing liposomes, and oil- emulsion were subcutaneously administered to 6-week-old turkeys. Charged liposomal avridine adjuvant, either positive or negative, produced a better antibody response than uncharged liposomal avridine or oil- emulsion adjuvants when used in a trivalent avian influenza vaccine. The antibody response to the different antigens was generally greater to the positively charged adjuvanted vaccine compared with the negatively or neutral charged or oil- emulsion adjuvanted vaccines and these differences were significant (P less than 0.05) with the three antigens. The results suggest that the positively charged liposomal avridine plays a significant role as adjuvant to the AIV antigens.
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Authors | O O Fatunmbi, J A Newman, V Sivanandan, D A Halvorson |
Journal | Vaccine
(Vaccine)
Vol. 10
Issue 9
Pg. 623-6
( 1992)
ISSN: 0264-410X [Print] Netherlands |
PMID | 1502840
(Publication Type: Journal Article)
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Chemical References |
- Adjuvants, Immunologic
- Antibodies, Viral
- Antigens, Viral
- Diamines
- Influenza Vaccines
- Liposomes
- avridine
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Topics |
- Adjuvants, Immunologic
(administration & dosage)
- Animals
- Antibodies, Viral
(biosynthesis)
- Antigens, Viral
(administration & dosage)
- Diamines
(administration & dosage)
- Electrochemistry
- Female
- Influenza A virus
(immunology)
- Influenza Vaccines
(administration & dosage)
- Influenza in Birds
(prevention & control)
- Liposomes
- Surface Properties
- Turkeys
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