Abstract | AIMS: METHODS:
PD-ECGF expression was measured by enzyme-linked immunosorbent assay in frozen materials from 134 colorectal cancer patients who had received curative resections. Patients were divided into high expression and low expression groups based upon selected cut-off value. Correlations among PD-ECGF expression, clinicopathologic features, and disease-free interval were studied by univariate and multivariate analysis. To evaluate the origin of PD-ECGF, serial sections of the 134 tumours were stained for PD-ECGF and CD68. RESULTS:
PD-ECGF expression in the normal mucosa was 34.4+/-15.5 (Units/mg protein) and the cut-off value was 65.4 (mean+2SD). There were no significant correlations between clinicopathological features and PD-ECGF expression. The disease-free interval for the high PD-ECGF expression group was significantly longer than that of the low expression group (P=0.05). A multivariate Cox's regression analysis revealed that high PD-ECGF expression is an independent factor for better outcome. In immunohistochemical study, almost all tumour cells were negative for PD-ECGF, but stromal macrophages were predominantly positive for PD-ECGF. CONCLUSIONS: The PD-ECGF expression originated from stromal macrophages was a predictor for favorable outcome after curative resections for colorectal cancer.
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Authors | T Tsuji, T Sawai, H Yamashita, H Takeshita, T Nakagoe, H Shindou, H Fukuoka, M Yoshinaga, S Hidaka, T Yasutake, T Nagayasu, Y Tagawa |
Journal | European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
(Eur J Surg Oncol)
Vol. 30
Issue 3
Pg. 296-302
(Apr 2004)
ISSN: 0748-7983 [Print] England |
PMID | 15028312
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Colectomy
(methods)
- Colorectal Neoplasms
(metabolism, surgery)
- Female
- Humans
- Male
- Middle Aged
- Predictive Value of Tests
- Prognosis
- Thymidine Phosphorylase
(biosynthesis)
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