Abstract | RATIONALE AND OBJECTIVES: METHODS: Thrombogenic material (0.23+/- 0.03 g) was implanted within the left atrium of 5 swine with induced atrial fibrillation. Scintigraphy was performed with a small field of view gamma camera (minimum of 400000 counts) 1 hour after implantation at 10, 60, and 120 minutes after the injection of the Tc-99m apcitide. Animals were then euthanized and a postmortem examination performed to confirm thrombus formation. RESULTS: : In all animals, thrombi and microthrombi were confirmed within the left atrial appendage. The average wet weight of the thrombus was 1.4 +/- 0.2 g. Tc-99m apcitide detected left atrial thrombus in all animals. CONCLUSIONS: This study suggests that AcuTect may prove useful for detecting intracardiac thrombus in future clinical studies in man.
|
Authors | Maj Jose C DeHoyos, Bernard J Rubal, Maj Yong C Bradley |
Journal | Investigative radiology
(Invest Radiol)
Vol. 39
Issue 4
Pg. 197-201
(Apr 2004)
ISSN: 0020-9996 [Print] United States |
PMID | 15021322
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
|
Chemical References |
- Organotechnetium Compounds
- Peptides, Cyclic
- Radiopharmaceuticals
- technetium Tc 99m P280
|
Topics |
- Acute Disease
- Animals
- Atrial Fibrillation
(complications)
- Female
- Heart Atria
(diagnostic imaging)
- Heart Diseases
(diagnostic imaging)
- Organotechnetium Compounds
- Peptides, Cyclic
- Radionuclide Imaging
- Radiopharmaceuticals
- Swine
- Thrombosis
(diagnostic imaging, etiology)
|