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Detection of acute atrial thrombus in a porcine model with atrial fibrillation with tc 99m-apcitide.

AbstractRATIONALE AND OBJECTIVES:
Technetium-99m apcitide (AcuTect) is a peptide with high affinity and specificity for glycoprotein IIb/IIIa receptors on platelets and is currently approved for the diagnosis of deep venous thrombosis. This study evaluates the use of Tc-99m apcitide for detecting intracardiac thrombus in an animal model with atrial fibrillation.
METHODS:
Thrombogenic material (0.23+/- 0.03 g) was implanted within the left atrium of 5 swine with induced atrial fibrillation. Scintigraphy was performed with a small field of view gamma camera (minimum of 400000 counts) 1 hour after implantation at 10, 60, and 120 minutes after the injection of the Tc-99m apcitide. Animals were then euthanized and a postmortem examination performed to confirm thrombus formation.
RESULTS:
: In all animals, thrombi and microthrombi were confirmed within the left atrial appendage. The average wet weight of the thrombus was 1.4 +/- 0.2 g. Tc-99m apcitide detected left atrial thrombus in all animals.
CONCLUSIONS:
This study suggests that AcuTect may prove useful for detecting intracardiac thrombus in future clinical studies in man.
AuthorsMaj Jose C DeHoyos, Bernard J Rubal, Maj Yong C Bradley
JournalInvestigative radiology (Invest Radiol) Vol. 39 Issue 4 Pg. 197-201 (Apr 2004) ISSN: 0020-9996 [Print] United States
PMID15021322 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Organotechnetium Compounds
  • Peptides, Cyclic
  • Radiopharmaceuticals
  • technetium Tc 99m P280
Topics
  • Acute Disease
  • Animals
  • Atrial Fibrillation (complications)
  • Female
  • Heart Atria (diagnostic imaging)
  • Heart Diseases (diagnostic imaging)
  • Organotechnetium Compounds
  • Peptides, Cyclic
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Swine
  • Thrombosis (diagnostic imaging, etiology)

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