Estriol treatment ameliorates disease in males with experimental autoimmune encephalomyelitis: implications for multiple sclerosis.

Abstract	Estrogen treatment has been found to be protective in experimental autoimmune encephalomyelitis (EAE) and possibly multiple sclerosis (MS). We investigated whether the effect of estrogen treatment is gender-specific. Estrogen receptor (ER) expressions, ERalpha and ERbeta, were found to be equivalent in both genders. EAE disease severity in both females and males was decreased with estriol treatment as compared to placebo. Finally, proinflammatory cytokine production during autoantigen-specific immune responses was decreased with estriol treatment in both females and males. These data support a potential role for estriol treatment for men in addition to women with MS.
Authors	Karen M Palaszynski, Hongbiao Liu, Kyi Kyi Loo, Rhonda R Voskuhl
Journal	Journal of neuroimmunology (J Neuroimmunol) Vol. 149 Issue 1-2 Pg. 84-9 (Apr 2004) ISSN: 0165-5728 [Print] Netherlands
PMID	15020068 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Cytokines Estrogen Receptor alpha Estrogen Receptor beta Glycoproteins Myelin-Oligodendrocyte Glycoprotein Peptide Fragments RNA, Messenger Receptors, Estrogen myelin oligodendrocyte glycoprotein (35-55) Estriol
Topics	Analysis of Variance Animals Cell Culture Techniques Cytokines (genetics, metabolism) Disease Models, Animal Encephalomyelitis, Autoimmune, Experimental (complications, drug therapy) Estriol (therapeutic use) Estrogen Receptor alpha Estrogen Receptor beta Female Glycoproteins (immunology) Lymphocytes (immunology, metabolism) Male Mice Mice, Inbred C57BL Multiple Sclerosis (drug therapy) Myelin-Oligodendrocyte Glycoprotein Peptide Fragments (immunology) RNA, Messenger (biosynthesis) Receptors, Estrogen (genetics, metabolism) Reverse Transcriptase Polymerase Chain Reaction (methods) Sex Characteristics Time Factors

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