Abstract | AIM AND METHOD: RESULTS: AdK1-3 and Adendo exerted inhibitory biological functions on endothelial cell proliferation, migration, and tube formation in vitro. AdK1-3 inhibited significantly endothelial cell infiltration in vascular endothelial growth factor embedded Matrigel plugs in mice whereas Adendo showed only minor effects. Both AdK1-3 and Adendo induced similar antitumour effects in the LLC tumour model in immune competent C57BL/6 mice but AdK1-3 had stronger inhibitory effects in athymic mice. Furthermore, AdK1-3 inhibited tumour growth in a murine CRC and human HCC model but was ineffective in a human CRC model. In contrast, Adendo did not reduce tumour progress in either of these tumour models although AdK1-3 and Adendo effectively reduced intratumoral microvessel density in LLC tumours. CONCLUSION:
|
Authors | V Schmitz, L Wang, M Barajas, C Gomar, J Prieto, C Qian |
Journal | Gut
(Gut)
Vol. 53
Issue 4
Pg. 561-7
(Apr 2004)
ISSN: 0017-5749 [Print] England |
PMID | 15016752
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
|
Topics |
- Adenoviridae
(genetics)
- Angiostatins
(genetics)
- Animals
- Carcinoma, Hepatocellular
(pathology, therapy)
- Carcinoma, Lewis Lung
(pathology, therapy)
- Colorectal Neoplasms
(pathology, therapy)
- Endostatins
(genetics)
- Genetic Therapy
(methods)
- Genetic Vectors
- Humans
- Liver Neoplasms
(pathology, therapy)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Nude
- Neovascularization, Pathologic
(prevention & control)
- Tumor Cells, Cultured
|