[Comparative study on antibacterial effects of huangqin-tang and its metabolites produced by intestinal flora].

Abstract

OBJECTIVE:

To compare the antibacterial effects of Huangqin-Tang with its metabolites produced by intestinal flora.

METHOD:

The antibacterial tests in vitro and in vivo were performed by agar dilution method and lethal protection of animal respectively.

RESULT:

Huangqin-Tang and its metabolites had antibacterial action on bacteria in vitro, however the antibacterial activity of metabolites of Huangqin-Tang on Salmomella, Dysentery bacillus and Proteus in vitro was stronger than Huangqin-Tang. The metabolites of Huangqin-Tang had protective effect on the animals infected by Staphylococcus aureus and Escherichia coli respectively from death, but Huangqin-Tang had no lethal protection action.

CONCLUSION:

The antibacterial effects of metabolites of Huangqin-Tang in vitro and in vivo are stronger than that of Huangqin-Tang, which shows that intestinal flora play a very important role in antibacterial effects of Huangqin-Tang.

• Authors: Mei-zhen Yan, Feng Zuo, Hong-yue Song, Wen-hua Ye, Zhong-ming Zhou
• Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 28 Issue 3 Pg. 243-6 (Mar 2003) ISSN: 1001-5302 [Print] China
• PMID: 15015311 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Drugs, Chinese Herbal
• Huangqin-Tang

Topics

• Animals
• Anti-Bacterial Agents (pharmacology, therapeutic use)
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Escherichia coli Infections (drug therapy)
• Feces (microbiology)
• Intestines (microbiology)
• Male
• Mice
• Phytotherapy
• Plants, Medicinal (chemistry)
• Proteus (drug effects)
• Salmonella (drug effects)
• Shigella dysenteriae (drug effects)
• Staphylococcal Infections (drug therapy)