| Abstract | Rarely may a non-hyperfunctioning thyroid nodule present as "hot" at Technetium-99m pertechnetate (99mTcO4-) and "cold" at radioiodine scintigraphy at late acquisitions. We report the case of a hyperthyroid female patient whose 99mTcO4- scintigraphy showed two "hot" nodules, whereas Iodide-131 (131I-) revealed a lack of indicator uptake by the larger, and intense uptake by the smaller nodule. The patient underwent surgery: histology demonstrated that the larger nodule, mismatched at pertechnetate vs iodine scintigraphy, was a papillary carcinoma. Our suggestion is to perform thyroid scintigraphy with radioiodine in hyperthyroid patients with more than one nodule concentrating pertechnetate, especially when an ultrasonographic pattern possibly suspect for malignancy is present. |
| Authors | L dell'Erba, P Gerundini, M Caputo, M Bagnasco
(Affiliation: Radiology Unit Viterbo-Di Carlo, Castellana Grotte, Bari, Italy. allerlab at unige.it)
|
| Journal | Journal of endocrinological investigation
(J Endocrinol Invest)
Vol. 26
Issue 11
Pg. 1124-7
(Nov 2003)
ISSN: 0391-4097 Italy |
| PMID | 15008253
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Iodine Radioisotopes
- Sodium Pertechnetate Tc 99m
|
| Topics |
- Carcinoma, Papillary
(radionuclide imaging)
- Female
- Humans
- Hyperthyroidism
(radionuclide imaging)
- Iodine Radioisotopes
(diagnostic use)
- Middle Aged
- Sodium Pertechnetate Tc 99m
(diagnostic use)
- Thyroid Neoplasms
(radionuclide imaging)
- Thyroid Nodule
(radionuclide imaging)
- Thyroidectomy
|
