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Photodynamic therapy for carcinoma in situ of the anus.

AbstractHYPOTHESIS:
Photodynamic therapy (PDT) for carcinoma in situ of the anus is an alternative to surgical excision in patients who are seropositive for human immunodeficiency virus (HIV).
DESIGN:
Before-after trial. Settings Tertiary referral center.
PATIENTS:
Twelve HIV-seropositive patients who were actively being treated for AIDS with high-grade dysplasia on anal Papanicolaou test results had site-directed biopsies of acetowhitening foci immediately after application of dilute acetic acid. Biopsy results showed that 5 patients had anal carcinoma in situ. These patients were given the photosensitizer delta-aminolevulinic acid orally. Four to 4.25 hours later, the entire anal circumference was treated with PDT. All 5 patients, after being treated with PDT, had repeated Papanicolaou tests at monthly intervals. If acetowhitening occurred at the fifth month, site-directed biopsy was done.
MAIN OUTCOME MEASURES:
Anal cytologic examination by Papanicolaou test and site-directed biopsy if acetowhitening was found at 5 months in order to determine effectiveness of PDT in downstaging cytologic findings.
RESULTS:
All patients had a consistent downgrading of cytologic findings during the 5 months of follow-up. Papanicolaou test results showed 2 patients had no dysplasia, 2 had mild dysplasia, and 1 had moderate dysplasia. Moderate dysplasia was confirmed by site-directed biopsy results. No complications of PDT occurred, but all 5 patients developed various abnormalities in liver function test results that returned to baseline values within 2 weeks; this also has been noted in patients ingesting delta-aminolevulinic acid who are presumably HIV seronegative.
CONCLUSION:
In a group of patients who are at high risk for recurrence irrespective of initial treatment, PDT can be used as a successful alternative to surgical excision for anal carcinoma in situ.
AuthorsJohn Webber, David Fromm
JournalArchives of surgery (Chicago, Ill. : 1960) (Arch Surg) Vol. 139 Issue 3 Pg. 259-61 (Mar 2004) ISSN: 0004-0010 [Print] United States
PMID15006881 (Publication Type: Clinical Trial, Journal Article)
Topics
  • Adult
  • Anus Neoplasms (drug therapy, pathology)
  • Biopsy
  • Carcinoma in Situ (drug therapy, pathology)
  • Humans
  • Male
  • Middle Aged
  • Photochemotherapy
  • Treatment Outcome

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