Abstract | PURPOSE: We evaluated the oxidative stress in renal tissue during three types of surgery: open donor nephrectomy (ODN), laparoscopic donor nephrectomy (LDN), and retroperitoneoscopic donor nephrectomy (RDN). The aim was to find out which is the appropriate procedure for harvesting a donor kidney. MATERIALS AND METHODS: RESULTS: Renal tissue GSH levels were decreased, whereas MDA levels were increased in groups II through IV compared with the control group (p<0.05). There was no statistically significant difference between the ODN, LDN, and RDN groups in the renal oxidative-stress markers. CONCLUSION: No differences were detected in oxidative-stress markers in renal tissue samples between ODN, LDN, and RDN. Therefore, we believe LDN and RDN can be used for live donor kidney harvesting as effectively as ODN without creating greater oxidative stress, which can have deleterious effects on a donor kidney.
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Authors | Murat Demirbas, Murat Samli, Yasemin Aksoy, Cem Guler, Asuman Kilinc, Cetin Dincel |
Journal | Journal of endourology
(J Endourol)
Vol. 18
Issue 1
Pg. 105-8
(Feb 2004)
ISSN: 0892-7790 [Print] United States |
PMID | 15006062
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Biomarkers
- Malondialdehyde
- Glutathione
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Topics |
- Animals
- Biomarkers
(analysis)
- Glutathione
(analysis)
- Kidney
(chemistry)
- Laparoscopy
(methods)
- Male
- Malondialdehyde
(analysis)
- Nephrectomy
(methods)
- Oxidative Stress
- Rabbits
- Retroperitoneal Space
- Tissue Donors
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