Abstract | OBJECTIVE: To evaluate the effect of intrathecal baclofen in a group of dystonic children using electrophysiological procedures previously validated in spastic children. METHODS: RESULTS: Motor-evoked potentials, present in 2 of 5 patients before baclofen, were preserved after injection. Before baclofen, H reflex was present in 6 of 7 patients (mean H(max)/M(max:) 0.45+/-0.21). It was markedly reduced after the injection (mean H(max)/M(max:) 0.09+/-0.11) (P<0.001). Area of flexor reflex significantly decreased after baclofen (P=0.047), while threshold significantly increased (P=0.01). No significant clinical improvement of the BADS scores was observed (P=0.058). CONCLUSIONS: These electrophysiological procedures, previously demonstrated to quantify the action of intrathecal baclofen in spastic adults and children, also appear sensitive in dystonic children. The electrophysiological changes are consistent with primarily spinal sites of action of baclofen. They appear more sensitive than clinical evaluation.
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Authors | Bernard Dachy, Bernard Dan |
Journal | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
(Clin Neurophysiol)
Vol. 115
Issue 4
Pg. 774-8
(Apr 2004)
ISSN: 1388-2457 [Print] Netherlands |
PMID | 15003756
(Publication Type: Clinical Trial, Journal Article)
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Chemical References |
- Muscle Relaxants, Central
- Baclofen
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Topics |
- Adult
- Baclofen
(administration & dosage)
- Cerebral Palsy
(complications)
- Child
- Child, Preschool
- Dystonia
(drug therapy, etiology, physiopathology)
- Evoked Potentials, Motor
(drug effects)
- Female
- H-Reflex
(drug effects)
- Humans
- Injections, Spinal
- Male
- Muscle Relaxants, Central
(administration & dosage)
- Neurodegenerative Diseases
(complications)
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