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The C-terminus of murine S100A9 inhibits hyperalgesia and edema induced by jararhagin.

Abstract
The effect of a synthetic peptide (H92-G110) identical to the C-terminus of murine S100A9 (mS100A9p) was investigated on hyperalgesia and edema induced by either jararhagin or papain in the rat paw. mS100A9p not only reverted hyperalgesia and edema induced by jararhagin, but also the highest concentration induced antinociception. Hemorrhage induced by jararhagin and its hydrolytic activity were inhibited by mS100A9p. These data suggest that mS100A9p might block jararhagin-induced hyperalgesia and edema by inhibiting jararhagin catalytic activity, since papain-induced hyperalgesia and edema were not inhibited by mS100A9p.
AuthorsCamila Squarzoni Dale, Luis Roberto de Camargo Gonçalves, Luiz Juliano, Maria Aparecida Juliano, Ana Maria Moura da Silva, Renata Giorgi
JournalPeptides (Peptides) Vol. 25 Issue 1 Pg. 81-9 (Jan 2004) ISSN: 0196-9781 [Print] United States
PMID15003359 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Calgranulin B
  • Crotalid Venoms
  • Platelet Aggregation Inhibitors
  • Metalloendopeptidases
  • jararhagin
Topics
  • Animals
  • Calgranulin B (chemistry, therapeutic use)
  • Crotalid Venoms
  • Edema (chemically induced, drug therapy)
  • Hyperalgesia (chemically induced, drug therapy)
  • Male
  • Metalloendopeptidases
  • Mice (metabolism)
  • Platelet Aggregation Inhibitors (pharmacology)
  • Rats
  • Rats, Wistar
  • Time Factors

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