Effect of ibuprofen on bilirubin-albumin binding.

Abstract

Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.

• Authors: Charles E Ahlfors
• Journal: The Journal of pediatrics (J Pediatr) Vol. 144 Issue 3 Pg. 386-8 (Mar 2004) ISSN: 0022-3476 [Print] United States
• PMID: 15001951 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Albumins
• Anti-Inflammatory Agents, Non-Steroidal
• Sulfisoxazole
• Bilirubin
• Ibuprofen

Topics

• Albumins (metabolism)
• Anti-Inflammatory Agents, Non-Steroidal (pharmacokinetics)
• Bilirubin (blood)
• Binding Sites
• Humans
• Ibuprofen (blood, pharmacokinetics)
• Infant, Newborn
• Jaundice, Neonatal (blood)
• Sulfisoxazole (pharmacokinetics)