Abstract | OBJECTIVE: METHODS: Rabbits underwent pulmonary artery banding 3 days after percutaneous right coronary artery injection of empty adenovirus (n = 19), a control adenovirus containing the beta-galactosidase transgene (n = 10), or an adenovirus containing the beta-adrenergic receptor kinase inhibitor transgene (n = 14). Sham-operated animals (n = 7) underwent instrumentation without deployment of the pulmonary artery band. Right ventricular function was assessed in each rabbit before and 7 days after pulmonary artery banding. Right ventricular mass and dimensions (surface area and volume) were obtained, and biochemical analysis was performed to confirm transgene expression and to characterize beta-adrenergic receptor signaling. RESULTS: CONCLUSIONS:
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Authors | Sitaram M Emani, Ashish S Shah, Michael K Bowman, David C White, Sitaramesh Emani, Donald D Glower, Walter J Koch |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 127
Issue 3
Pg. 787-93
(Mar 2004)
ISSN: 0022-5223 [Print] United States |
PMID | 15001908
(Publication Type: Journal Article)
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Chemical References |
- Carrier Proteins
- Peptides
- Receptors, Adrenergic, beta
- Recombinant Proteins
- beta-adrenergic receptor kinase inhibitory peptide
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Topics |
- Adenoviridae
- Animals
- Carrier Proteins
(genetics, metabolism)
- Gene Transfer Techniques
- Genetic Therapy
- Hypertrophy, Right Ventricular
(etiology, genetics, metabolism, prevention & control)
- Ligation
- Peptides
- Pulmonary Artery
(surgery)
- Rabbits
- Receptors, Adrenergic, beta
(metabolism)
- Recombinant Proteins
- Ventricular Dysfunction, Right
(etiology, genetics, metabolism, prevention & control)
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