Hepatocyte nuclear factor-1 alpha gene inactivation: cosegregation between liver adenomatosis and diabetes phenotypes in two maturity-onset diabetes of the young (MODY)3 families.

Abstract	Heterozygous germline mutations of the hepatocyte nuclear factor (HNF)-1 alpha are associated with maturity-onset diabetes of the young (MODY)3. Recently, the biallelic inactivation of the HNF-1 alpha gene was reported in liver adenomas. We show the occurrence of liver adenomatosis in six MODY3-affected patients from two unrelated and large families. Liver adenomatosis was characterized by the presence of numerous adenomas within a normal hepatic parenchyma. The HNF-1 alpha hot-spot germline mutation P291fs was identified in the two probands and in 16 relatives from the two families. The six patients affected by liver adenomatosis and diabetes exhibited the mutation. The analysis of liver-cell tumors from two affected patients evidenced the biallelic inactivation of HNF-1 alpha. The familial screening confirmed the clinical heterogeneity of the liver phenotype, from silent liver adenomatosis to fatal hemorrhage. These observations warrant the systematic screening for liver adenomatosis in MODY3 families to prevent its potentially deadly complications. Moreover, such screening may help to determine if a particular mutational spectrum of HNF-1 alpha is associated with liver adenomatosis and to establish its prevalence in this frequent form of diabetes in the young adult.
Authors	Yves Reznik, Thong Dao, Regis Coutant, Laurence Chiche, Emmanuelle Jeannot, Severine Clauin, Pierre Rousselot, Monique Fabre, Frederic Oberti, Armelle Fatome, Jessica Zucman-Rossi, Christine Bellanne-Chantelot
Journal	The Journal of clinical endocrinology and metabolism (J Clin Endocrinol Metab) Vol. 89 Issue 3 Pg. 1476-80 (Mar 2004) ISSN: 0021-972X [Print] United States
PMID	15001650 (Publication Type: Journal Article)
Chemical References	DNA-Binding Proteins HNF1A protein, human HNF1B protein, human Hepatocyte Nuclear Factor 1-alpha Nuclear Proteins Transcription Factors Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-beta
Topics	Adenoma (genetics, pathology) Adolescent Adult DNA-Binding Proteins Diabetes Mellitus, Type 2 (genetics) Family Health Female Genetic Testing Hepatocyte Nuclear Factor 1 Hepatocyte Nuclear Factor 1-alpha Hepatocyte Nuclear Factor 1-beta Humans Liver (pathology) Liver Neoplasms (genetics, pathology) Male Middle Aged Nuclear Proteins Pedigree Phenotype Transcription Factors (genetics)

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