| Abstract | The protection conferred by the reduced-dose Rev 1 Brucella melitensis vaccine in goats that had been immunized 5 years previously was evaluated. Sixteen goats vaccinated 5 years before with Rev 1 (1 x 10(5) cfu) and 5 non-vaccinated goats were challenged with B. melitensis 16M (4 x 10(5) cfu) using the conjunctival route. After giving birth or aborting, the goats were sacrificed and tissue samples were taken for bacteriological study. The challenge strain was recovered in 12%, of the animals from the vaccinated group, and in (80% of the control group. It is concluded, therefore that the use of reduced-dose Rev 1 protects goats vaccinated in endemic areas for at least 5 years after immunization. |
| Authors | E Díaz-Aparicio, L Hernández, F Suárez-Güemes
(Affiliation: CENID Microbiología, Instituto Nacional de Investigaciones Agrícolas, Forestales y Pecuarias, Carretera Federal México-Toluca Km. 15.5, Cuajimalpa, Mexico. diaz at ciml.univ-mrs.fr)
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| Journal | Tropical animal health and production
(Trop Anim Health Prod)
Vol. 36
Issue 2
Pg. 117-21
(Feb 2004)
ISSN: 0049-4747 United States |
| PMID | 14998310
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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| Chemical References |
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| Topics |
- Animals
- Brucella Vaccine
(administration & dosage, immunology)
- Brucella melitensis
(immunology)
- Brucellosis
(prevention & control, veterinary)
- Colony Count, Microbial
(veterinary)
- Conjunctiva
- Dose-Response Relationship, Immunologic
- Female
- Goat Diseases
(prevention & control)
- Goats
- Time Factors
|
