The role of CD44v3 expression in female breast carcinomas.

Abstract

CD44-protein and its isoforms are the multifunctional cell adhesion molecules participating in cell-cell and cell-matrix interactions. In this study we estimated the frequency of CD44-expression as well as two of its variants (CD44v3 and CD44v5) in female breast cancer. Among 75 breast carcinomas studied, 23 (44.2%) presented strong membrane reaction with monoclonal antibody against antigen CD44. The immunocytochemical reaction to CD44v3 and CD44v5 were observed in 16 (21.3%) and 50 (66.75%) cases, respectively. The presence of CD44v3 antigen on the surface of breast cancer cells significantly correlated with ER expression (0.0430) and the lack of p53 protein (p=0.0252), and also with the percentage of T cells in the total population of lymphocytes infiltrating the primary tumor (TILs) (p=0.0248). What is more important, the reaction to CDv3 significantly correlated with the presence of metastases to the lymph nodes (p=0.0385).

• Authors: Janusz Ryś, Anna Kruczak, Bozena Lackowska, Agnieszka Jaszcz-Gruchała, Anna Brandys, Andrzej Stelmach, Marian Reinfuss
• Journal: Polish journal of pathology : official journal of the Polish Society of Pathologists (Pol J Pathol) Vol. 54 Issue 4 Pg. 243-7 ( 2003) ISSN: 1233-9687 [Print] Poland
• PMID: 14998292 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• CD44V3,8-10
• CD44v5 antigen
• Hyaluronan Receptors

Topics

• Adenocarcinoma (metabolism, secondary)
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (metabolism, pathology)
• Female
• Humans
• Hyaluronan Receptors (metabolism)
• Immunohistochemistry
• Immunophenotyping
• Lymphatic Metastasis (pathology)
• T-Lymphocytes (metabolism, pathology)