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Improved health-related quality of life following a randomized controlled trial of alefacept treatment in patients with chronic plaque psoriasis.

AbstractBACKGROUND:
Psoriasis has a negative impact on patients' quality of life. Treatment strategies should address both the cutaneous manifestations of the disease and their impact on quality of life.
OBJECTIVES:
To evaluate the effect of alefacept on quality of life in 553 patients with chronic plaque psoriasis.
METHODS:
In this multicentre, double-blind, parallel-groups study, patients were randomized to receive alefacept for two courses, alefacept in course 1 and placebo in course 2, or placebo in course 1 and alefacept in course 2. In each course, alefacept 7.5 mg or placebo was administered once weekly by 30-s intravenous injection for 12 weeks followed by 12 weeks of observation. The Dermatology Life Quality Index (DLQI), Dermatology Quality of Life Scales (DQOLS) and Short Form-36 Health Survey (SF-36) were administered at baseline, 2 weeks after the last dose in both courses, at the beginning of course 2, and at the end of the observation period in both courses.
RESULTS:
In course 1, alefacept significantly reduced (improved) mean DLQI scores compared with placebo: 4.4 vs. 1.8 at 2 weeks after the last dose (P<0.0001) and 3.4 vs. 1.4 at 12 weeks after the last dose (P<0.001). Patients who received two courses of alefacept experienced additional enhancement of quality of life measures during the second course. Similar results were observed for the DQOLS. The SF-36 survey confirmed that alefacept had no negative impact on general quality of life.
CONCLUSIONS:
Alefacept improved quality of life in patients with chronic plaque psoriasis and maintained this benefit for at least 12 weeks following cessation of treatment. A second course of alefacept provided additional quality of life benefit.
AuthorsS R Feldman, A Menter, J Y Koo
JournalThe British journal of dermatology (Br J Dermatol) Vol. 150 Issue 2 Pg. 317-26 (Feb 2004) ISSN: 0007-0963 [Print] England
PMID14996104 (Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Dermatologic Agents
  • Recombinant Fusion Proteins
  • alefacept
Topics
  • Adolescent
  • Adult
  • Aged
  • Chronic Disease
  • Dermatologic Agents (administration & dosage)
  • Double-Blind Method
  • Female
  • Health Status Indicators
  • Health Surveys
  • Humans
  • Injections, Intravenous
  • Male
  • Middle Aged
  • Psoriasis (drug therapy)
  • Quality of Life
  • Recombinant Fusion Proteins (administration & dosage)
  • Surveys and Questionnaires
  • Treatment Outcome

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