[Effect of perftoran on the oxidant-antioxidant system in patients with severe trauma and blood loss].

Abstract

Diminution of reperfusion and re-oxygenation lesions is an important task in the treatment of patients with severe injury and blood loss. From this standpoint the influence of perforan on the condition of the oxidant-antioxidant system was studied in patients with severe combined trauma. The application of perftoran in the early post-trauma period was found to intensify the processes of lipid peroxidation and, simultaneously, to normalize the parameters of the antioxidant-protection system.

• Authors: D A Ostapchenko, S M Radaev, L V Gerasimov, E R Nemtsova, T V Sergeeva, A V Vlasenko
• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2003 Nov-Dec Issue 6 Pg. 13-5 ISSN: 0201-7563 [Print] Russia (Federation)
• Vernacular Title: Vliianie perftorana na sostoianie oksidantno-antioksidantnoĭ sistemy u bol'nykh s tiazheloĭ travmoĭ i krovopotereĭ.
• PMID: 14991970 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Colloids
• Crystalloid Solutions
• Fluorocarbons
• Isotonic Solutions
• Plasma Substitutes
• Malondialdehyde
• perftoran
• Ceruloplasmin
• Lactoferrin

Topics

• APACHE
• Adult
• Ceruloplasmin (metabolism)
• Colloids (administration & dosage)
• Crystalloid Solutions
• Erythrocyte Transfusion
• Female
• Fluorocarbons (administration & dosage, therapeutic use)
• Hemorrhage (complications, metabolism, therapy)
• Humans
• Infusions, Parenteral
• Isotonic Solutions
• Lactoferrin (blood)
• Lipid Peroxidation (drug effects)
• Male
• Malondialdehyde (blood)
• Multiple Trauma (complications, metabolism, therapy)
• Plasma Exchange
• Plasma Substitutes (administration & dosage)
• Trauma Severity Indices
• Treatment Outcome