Abstract | BACKGROUND & AIMS: Injury to the intestinal mucosa is frequently a dose-limiting complication of radiotherapy and chemotherapy. Approaches to limit the damage to the intestine during radiation and chemotherapy have been largely ineffective. Trefoil factors are produced throughout the gastrointestinal tract and regulate cell migration, restitution, and repair. Studies were undertaken to define the role of intestinal trefoil factor in modulating the intestinal response to chemotherapy and radiation. METHODS: RESULTS: CONCLUSIONS:
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Authors | P L Beck, J F Wong, Y Li, S Swaminathan, R J Xavier, K L Devaney, Daniel K Podolsky |
Journal | Gastroenterology
(Gastroenterology)
Vol. 126
Issue 3
Pg. 796-808
(Mar 2004)
ISSN: 0016-5085 [Print] United States |
PMID | 14988834
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Mucins
- Muscle Proteins
- Neuropeptides
- Peptides
- Recombinant Proteins
- TFF3 protein, rat
- Trefoil Factor-2
- Trefoil Factor-3
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Topics |
- Animals
- Disease Susceptibility
- Drug-Related Side Effects and Adverse Reactions
- Enteritis
(chemically induced, etiology)
- Intestinal Mucosa
(drug effects, metabolism, radiation effects)
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mucins
- Muscle Proteins
- Neuropeptides
- Peptides
(deficiency, metabolism, pharmacology)
- Radiotherapy
(adverse effects)
- Recombinant Proteins
(pharmacology)
- Trefoil Factor-2
- Trefoil Factor-3
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