Abstract | BACKGROUND & AIMS:
Gallstone disease is an important, costly health-care problem in Western societies. It is still unclear whether hepatic lipid regulatory enzymes play primary or secondary roles in gallstone formation. In this study, the aim was to investigate whether the synthesis of bile acids and cholesterol is increased in gallstone disease and to test whether such a metabolic change, if present, might occur before gallstone formation. METHODS: RESULTS: CONCLUSIONS:
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Authors | Cecilia Gälman, Juan Francisco Miquel, Rosa Maria Pérez, Curt Einarsson, Lars Ståhle, Guillermo Marshall, Flavio Nervi, Mats Rudling |
Journal | Gastroenterology
(Gastroenterology)
Vol. 126
Issue 3
Pg. 741-8
(Mar 2004)
ISSN: 0016-5085 [Print] United States |
PMID | 14988828
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Bile Acids and Salts
- Cholestenones
- 7 alpha-hydroxy-4-cholesten-3-one
- lathosterol
- Cholesterol
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Topics |
- Adult
- Bile Acids and Salts
(biosynthesis)
- Case-Control Studies
- Chile
(ethnology)
- Cholestenones
(blood)
- Cholesterol
(blood)
- Female
- Gallstones
(blood, etiology)
- Hispanic or Latino
- Humans
- Indians, South American
- Middle Aged
- Risk Factors
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