HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Paternal and maternal age as risk factors for psychosis: findings from Denmark, Sweden and Australia.

AbstractBACKGROUND:
While the association between increased maternal age and congenital disorders has long been recognized, the offspring of older fathers are also at increased risk of congenital disorders related to DNA errors during spermatogenesis. Recent studies have drawn attention to an association between increased paternal age and increased risk of schizophrenia. The aim of the current study was to examine both paternal and maternal age as risk factors for the broader category of psychosis.
METHOD:
We used data from three sources examining psychosis: a population-based cohort study (Denmark), and two case-control studies (Sweden and Australia).
RESULTS:
When controlling for the effect of maternal age, increased paternal age was significantly associated with increased risk of psychosis in the Danish and Swedish studies. The Australian study found no association between adjusted paternal age and risk of psychosis. When controlling for the effect of paternal age, younger maternal age was associated with an increased risk of psychoses in the Danish study alone.
CONCLUSIONS:
The offspring of older fathers are at increased risk of developing psychosis. The role of paternally derived mutations and/or psychosocial factors associated with older paternal age warrants further research.
AuthorsOssama El-Saadi, Carsten B Pedersen, Thomas F McNeil, Sukanta Saha, Joy Welham, Eadbhard O'Callaghan, Elizabeth Cantor-Graae, David Chant, Preben Bo Mortensen, John McGrath
JournalSchizophrenia research (Schizophr Res) Vol. 67 Issue 2-3 Pg. 227-36 (Apr 01 2004) ISSN: 0920-9964 [Print] Netherlands
PMID14984882 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Adolescent
  • Adult
  • Age Factors
  • Australia (epidemiology)
  • Case-Control Studies
  • Denmark (epidemiology)
  • Family Health
  • Female
  • Humans
  • Male
  • Maternal Age
  • Middle Aged
  • Odds Ratio
  • Paternal Age
  • Prospective Studies
  • Psychotic Disorders (classification, epidemiology)
  • Risk Assessment
  • Risk Factors
  • Sex Factors
  • Sweden (epidemiology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: