Abstract |
Amyloid-like pulmonary nodules have been described in patients with systemic light-chain deposition disease, but their significance in other clinical contexts is unknown. We examined biopsy specimens of amyloid-like pulmonary nodules from 3 women without systemic light-chain deposition disease. Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of kappa light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. Patients 2 (aged 65 years) and 3 (aged 69 years) had asymptomatic solitary pulmonary nodules. In all cases, electron microscopic examination showed dense granular extracellular deposits without the fibrillary characteristics of amyloid. Amyloid-like nodules should be distinguished from nodular amyloidosis and, in some patients, might represent a localized form of light-chain deposition.
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Authors | Andras Khoor, Jeffrey L Myers, Henry D Tazelaar, Paul J Kurtin |
Journal | American journal of clinical pathology
(Am J Clin Pathol)
Vol. 121
Issue 2
Pg. 200-4
(Feb 2004)
ISSN: 0002-9173 [Print] England |
PMID | 14983932
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Amyloid
- Immunoglobulin kappa-Chains
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Topics |
- Aged
- Amyloid
(metabolism, ultrastructure)
- Amyloidosis
(metabolism, pathology)
- Female
- Humans
- Immunoenzyme Techniques
- Immunoglobulin kappa-Chains
(metabolism)
- Lung
(metabolism, pathology)
- Microscopy, Electron
- Middle Aged
- Solitary Pulmonary Nodule
(immunology, metabolism, pathology)
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