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Amyloid-like pulmonary nodules, including localized light-chain deposition: clinicopathologic analysis of three cases.

Abstract
Amyloid-like pulmonary nodules have been described in patients with systemic light-chain deposition disease, but their significance in other clinical contexts is unknown. We examined biopsy specimens of amyloid-like pulmonary nodules from 3 women without systemic light-chain deposition disease. Patient 1 (aged 62 years) had multiple pulmonary nodules and underwent 2 separate lung biopsies, the first showing nodules composed of kappa light-chain deposits accompanied by low-grade lymphoplasmacytic lymphoma limited to the lung and the second, obtained after chemotherapy 9 months later, showing only residual nodules without persistent lymphoma. Patients 2 (aged 65 years) and 3 (aged 69 years) had asymptomatic solitary pulmonary nodules. In all cases, electron microscopic examination showed dense granular extracellular deposits without the fibrillary characteristics of amyloid. Amyloid-like nodules should be distinguished from nodular amyloidosis and, in some patients, might represent a localized form of light-chain deposition.
AuthorsAndras Khoor, Jeffrey L Myers, Henry D Tazelaar, Paul J Kurtin
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 121 Issue 2 Pg. 200-4 (Feb 2004) ISSN: 0002-9173 [Print] England
PMID14983932 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Amyloid
  • Immunoglobulin kappa-Chains
Topics
  • Aged
  • Amyloid (metabolism, ultrastructure)
  • Amyloidosis (metabolism, pathology)
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Immunoglobulin kappa-Chains (metabolism)
  • Lung (metabolism, pathology)
  • Microscopy, Electron
  • Middle Aged
  • Solitary Pulmonary Nodule (immunology, metabolism, pathology)

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