[Clinical application of proton MR spectroscopy to hyperacute ischemic brain disease].

Abstract

We examined the usefulness of proton magnetic resonance spectroscopy ((1)H-MRS) for imaging diagnosis in 50 outpatients and 42 emergency patients with hyperacute ischemic brain disease. In hyperacute ischemic brain disease, a reduction of N-acetylaspartate and the appearance of lactate were found in the spectrum from immediately after the development of symptoms. Thereafter, a decrease in N-acetylaspartate and increase in lactate was observed with time, and the pattern of the spectrum was categorized. Moreover, evaluation of the penumbra was considered, including its relation with the intra-arterial signal as determined by the T(2) fluid-attenuated inversion recovery image of magnetic resonance imaging. Our results obtained from the use of proton MR spectroscopy to perform cerebral evaluation on a cellular level were examined by evaluation of the ischemic penumbra of an ischemic brain disease, and were considered to be useful.

• Authors: Mitsuru Ichihara, Yuki Nakamura, Tomohiko Okawa
• Journal: Nihon Hoshasen Gijutsu Gakkai zasshi (Nihon Hoshasen Gijutsu Gakkai Zasshi) Vol. 59 Issue 11 Pg. 1414-23 (Nov 2003) ISSN: 0369-4305 [Print] Japan
• PMID: 14983129 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Protons

Topics

• Acute Disease
• Brain Ischemia (diagnosis)
• Humans
• Image Processing, Computer-Assisted (instrumentation, methods)
• Magnetic Resonance Imaging
• Magnetic Resonance Spectroscopy (instrumentation, methods)
• Protons
• Retrospective Studies
• Software
• Time Factors