Abstract | OBJECTIVE: The effect of AT-1015, a serotonin(2A) receptor antagonist, on the resaturation of ischemic muscle in a hypercholesterolemic rabbit model was examined with near-infrared spectroscopy. METHODS: New Zealand White male rabbits were fed normal chow or cholesterol-rich chow. Ischemia was induced in the right hindlimb by ligation of the femoral artery, accompanied by balloon injury of the iliac artery. At 3 days after induction of ischemia, the bilateral gastrocnemius muscles were subjected to passive contraction for 2 minutes. The oxygen resaturation time of the gastrocnemius muscle after exercise was measured by near-infrared spectroscopy. AT-1015 was orally administered for 3 days after induction of ischemia. Assay of serotonin level in platelet-poor plasma and histologic examination of muscle and artery were performed in another set of rabbits. RESULTS:
Oxygen resaturation time of the ischemic gastrocnemius was significantly prolonged in hypercholesterolemic rabbits compared with in normal rabbits without AT-1015, whereas there was no difference between both groups of rabbits that were administered AT-1015. Plasma level of serotonin in hypercholesterolemic rabbits was significantly increased compared with that in normal rabbits. No histologic differences were found in both muscle and artery among all groups. CONCLUSIONS:
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Authors | Takashi Komiyama, Hideaki Kihara, Ken Hirose, Ryota Yoshimoto, Hiroshi Shigematsu |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 39
Issue 3
Pg. 661-7
(Mar 2004)
ISSN: 0741-5214 [Print] United States |
PMID | 14981464
(Publication Type: Journal Article)
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Chemical References |
- Isonipecotic Acids
- N-(2-(4-(5H-dibenzo(a,d)cyclohepten-5-yliden)piperidino)ethyl)-1-formyl-4-piperidinecarboxamide
- Serotonin 5-HT2 Receptor Antagonists
- Serotonin
- Oxygen
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Topics |
- Animals
- Hypercholesterolemia
(blood, metabolism)
- Ischemia
(metabolism)
- Isonipecotic Acids
(pharmacology)
- Male
- Models, Animal
- Muscle, Skeletal
(blood supply, drug effects)
- Oxygen
(metabolism)
- Physical Conditioning, Animal
(physiology)
- Rabbits
- Serotonin
(blood)
- Serotonin 5-HT2 Receptor Antagonists
- Spectroscopy, Near-Infrared
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