Laparoscopic splenectomy for autoimmune hemolytic anemia in patients with chronic lymphocytic leukemia: a case series and review of the literature.

Abstract

The purpose of this study was to evaluate the safety and efficacy of laparoscopic splenectomy in patients with chronic lymphocytic leukemia (CLL) complicated by autoimmune hemolytic anemia. A series of nine such patients who underwent this procedure at our institution between August 1997 and September 2001 were retrospectively reviewed. Seven of 9 patients who underwent laparoscopic splenectomy for CLL and autoimmune hemolytic anemia achieved a complete response. One patient who initially responded relapsed 12 weeks postoperatively. Therefore, six of 9 patients showed sustained responses with a mean follow-up of 2 years, consistent with other published series. Two patients had no response, one of whom died within 3 weeks of surgery from transformed Hodgkin's disease. The only other postoperative complication occurred in a patient who developed pneumonia. We conclude that laparoscopic splenectomy is a safe and effective treatment for autoimmune hemolytic anemia in patients with CLL who fail medical therapy.

• Authors: John Hill, R Matthew Walsh, Scott McHam, Fred Brody, Matt Kalaycio
• Journal: American journal of hematology (Am J Hematol) Vol. 75 Issue 3 Pg. 134-8 (Mar 2004) ISSN: 0361-8609 [Print] United States
• PMID: 14978692 (Publication Type: Journal Article, Review)
• Copyright: Copyright 2004 Wiley-Liss, Inc.

Topics

• Aged
• Anemia, Hemolytic, Autoimmune (blood, complications, surgery)
• Case-Control Studies
• Female
• Follow-Up Studies
• Humans
• Laparoscopy (adverse effects, methods, mortality)
• Leukemia, Lymphocytic, Chronic, B-Cell (blood, complications)
• Male
• Middle Aged
• Recurrence
• Retrospective Studies
• Splenectomy (adverse effects, methods, mortality)
• Treatment Outcome