Abstract | OBJECTIVE: METHODS: By adopting the multi-centered, randomized and controlled method, the patients were divided in to the QGHXR group (60 patients) treated orally by QGHXR, the XCHG group (30 patients) treated orally by Xiaochaihu granule and the control group (30 patients) treated orally by conventional therapy such as glucurolactone, vitamin C. The changes in symptoms, signs, liver function, blood lipid, liver fibrosis markers, cytokines, lipid superoxidation parameters and B-untrasonographic figure after treatment of the two groups were observed. RESULTS: CONCLUSION: QGHXR shows obvious therapeutic effect in treating ALD, the mechanism could possibly be related with its effects in antagonizing lipid superoxidation, stabilizing hepatic cell membrane, adjusting the lipid metabolic disturbance of liver, regulating immune function, anti- liver fibrosis and promoting the intrahepatic metabolism of alcohol.
|
Authors | Guang Ji, Yu-qun Wang, Cheng-lou Cao |
Journal | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine
(Zhongguo Zhong Xi Yi Jie He Za Zhi)
Vol. 24
Issue 1
Pg. 13-6
(Jan 2004)
ISSN: 1003-5370 [Print] China |
PMID | 14976881
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Drugs, Chinese Herbal
- shosaiko-to
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Drugs, Chinese Herbal
(therapeutic use)
- Fatty Liver, Alcoholic
(drug therapy)
- Female
- Humans
- Liver Cirrhosis, Alcoholic
(drug therapy)
- Liver Diseases, Alcoholic
(drug therapy)
- Male
- Middle Aged
- Phytotherapy
|