Glucosyl hesperidin improves serum cholesterol composition and inhibits hypertrophy in vasculature.

Abstract

Long-term administration of hesperidin (HES) or glucosyl hesperidin (GHES), a water-soluble analogue of HES, brings about an antihypertensive effect on spontaneously hypertensive rats (SHR). In the present study, we investigated the effects of long-term administration of HES and GHES (corresponding to 30 mg/d/kg body weight) on serum lipid concentration and morphology of vasculature. Serum HDL cholesterol increased in both SHR and Wistar-Kyoto rats (WKY) fed a HES- or GHES-containing diet for 25 wk. Simultaneously, GHES administration reduced the vascular diameter and media-intimal cross-sectional area of the abdominal aorta in SHR. These results suggest that HES as well as GHES improves serum cholesterol composition and that GHES inhibits hypertrophy in vasculature as well.

• Authors: Kazumasa Ohtsuki, Asaki Abe, Hitoshi Mitsuzumi, Masaru Kondo, Kanae Uemura, Yumiko Iwasaki, Yasuhiro Kondo
• Journal: Journal of nutritional science and vitaminology (J Nutr Sci Vitaminol (Tokyo)) Vol. 49 Issue 6 Pg. 447-50 (Dec 2003) ISSN: 0301-4800 [Print] Japan
• PMID: 14974738 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Cholesterol, LDL
• Glucosides
• Triglycerides
• glucosyl hesperidin
• Cholesterol
• Hesperidin

Topics

• Animals
• Aorta, Abdominal (drug effects, pathology)
• Blood Vessels (pathology)
• Cholesterol (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• Coronary Vessels (drug effects, pathology)
• Glucosides (administration & dosage)
• Hesperidin (administration & dosage, analogs & derivatives)
• Hypertension (blood, pathology)
• Hypertrophy
• Rats
• Rats, Inbred SHR
• Rats, Inbred WKY
• Triglycerides (blood)