Abstract | BACKGROUND: Although n- alkanes accumulate in some disorders of cornification, recent studies using radioactive carbon 14 content by accelerator mass spectrometry point to an exogenous origin for alkanes in normal stratum corneum, and their derivation in congenital ichthyosiform erythroderma remains controversial. DESIGN AND RESULTS: CONCLUSIONS: These data demonstrate that scale n- alkanes in disorders of cornification derive from environmental sources and indicate the pervasiveness of petroleum-based emollients in skin. Therefore, epidermal lipid analyses must be interpreted with caution. However, these studies do not rule out an important therapeutic and/or pathogenic role for exogenous n- alkanes in skin.
|
Authors | M L Williams, J S Vogel, R Ghadially, B E Brown, P M Elias |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 128
Issue 8
Pg. 1065-71
(Aug 1992)
ISSN: 0003-987X [Print] United States |
PMID | 1497360
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
|
Chemical References |
|
Topics |
- Adult
- Alkanes
(analysis, pharmacokinetics)
- Animals
- Humans
- Ichthyosiform Erythroderma, Congenital
(metabolism, pathology)
- Lipid Metabolism
- Lipids
(analysis)
- Male
- Mice
- Mice, Hairless
- Microscopy, Electron
- Skin
(chemistry, metabolism, ultrastructure)
- Tissue Distribution
|