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Structure and properties of lipid bilayer of erythrocyte membranes in patients with malignant tumors.

Abstract
The study of erythrocyte membranes in untreated patients with malignant tumors of different location (lung cancer, tumors of the head and neck, stomach and colorectal cancer) revealed changes in the fatty-acid spectrum of phospholipid fraction paralleled by an increase in the viscosity of the lipid bilayer, including the area of protein-lipid contacts. The degree of changes depended on tumor location.
AuthorsE A Stepovaya, V V Novitskii, N V Ryazantseva, V E Goldberg, S B Tkachenko, M V Kolosova
JournalBulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 136 Issue 5 Pg. 490-3 (Nov 2003) ISSN: 0007-4888 [Print] United States
PMID14968169 (Publication Type: Journal Article)
Chemical References
  • Fatty Acids
  • Lipid Bilayers
Topics
  • Adult
  • Aged
  • Case-Control Studies
  • Erythrocyte Membrane (chemistry, metabolism)
  • Fatty Acids (analysis, chemistry)
  • Female
  • Humans
  • Lipid Bilayers (chemistry, metabolism)
  • Male
  • Middle Aged
  • Neoplasms (blood, pathology)
  • Spectrometry, Fluorescence
  • Structure-Activity Relationship
  • Viscosity

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