Combined action of doxorubicin and gestagens on doxorubicin-sensitive and doxorubicin-resistant MCF-7 cells.

Abstract

The combined cytostatic effect of doxorubicin and gestagens progesterone, medroxyprogesterone acetate, mecigestone, and butagest on doxorubicin-resistant and doxorubicin-sensitive human breast cancer MCF-7 cells was studied by the MTT assay. On the 6th day of incubation progesterone, medroxyprogesterone acetate, mecigestone, and butagest in high concentrations (10(-5) M) potentiated the cytostatic action of doxorubicin in sensitive and resistant cells by 30-50%. Potentiation of the cytostatic effect produced by doxorubicin in sensitive cells is related to intrinsic cytotoxic activity of gestagens. In resistant cells these changes are associated with potentiation of the effect of doxorubicin.

• Authors: P V Sergeev, A V Semeikin, T A Fedotcheva, R V Samoilikov, A V Kamernitskii, I S Levina, V M Rzheznikov, G S Grinenko, Yu N Korystov, N V Ermakova, V V Shaposhnikova, N L Shimanovskii
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 136 Issue 5 Pg. 460-3 (Nov 2003) ISSN: 0007-4888 [Print] United States
• PMID: 14968160 (Publication Type: Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Progestins
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (pharmacology)
• Antineoplastic Combined Chemotherapy Protocols (pharmacology)
• Breast Neoplasms (drug therapy)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Doxorubicin (administration & dosage)
• Drug Resistance, Neoplasm
• Drug Synergism
• Humans
• Progestins (administration & dosage, chemistry)