[Protein synthesizing cell apparatus in malignant growth and pharmacotherapy by chlofiden].

Abstract

Data on the influence of a new antitumor preparation chlofiden on the general contents of rat liver ribosomes and sarcoma 45 and their division on free and membrane of membrane bound and decrease of free ribosomes during tumor growth supposed synthesis of specific proteins bound are given in the paper. It was shown that in the liver of tumor bearing rats total and membrane bound ribosomes decreased and the level of free ribosomes increased. High contents of free ribosomes in sarcoma 45 may testify increase of intracellular protein synthesis including processes of cell growth and division as well as the tendency for increase. Chlofiden normalized total contents, increased free and decreased liver membrane bound ribosomes contents, during tumor growth supposed synthesis of specific proteins. Increase of free ribosomes and decrease of their specific radioactivity in sarcoma 45 testified membrane damage by chlofiden and inhibition of intracellular protein synthesis which are essential in cell division.

• Authors: N I Sharykina, I G Kudriavtseva, G P Pavlovskaia
• Journal: Ukrains'kyi biokhimichnyi zhurnal (1999 ) (Ukr Biokhim Zh (1999)) 2002 Jul-Aug Vol. 74 Issue 4 Pg. 80-4 Ukraine
• Vernacular Title: Beloksinteziruiushchiĭ apparat kletok pri zlokachestvennom roste i farmakoterapii khlofidénom.
• PMID: 14964866 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antineoplastic Agents
• Chlofiden
• Ethylamines
• Ribosomal Proteins

Topics

• Animals
• Antineoplastic Agents (pharmacology)
• Cell Differentiation
• Ethylamines (pharmacology)
• Liver (metabolism)
• Male
• Rats
• Ribosomal Proteins (biosynthesis)
• Ribosomes (metabolism)
• Sarcoma, Experimental (metabolism, pathology)
• Tumor Cells, Cultured