Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage.

Photorejuvenation involves the use of a light source or laser in reversing the signs of aging. The Intense Pulsed Light (IPL) has demonstrated effectiveness in treating signs of photodamage. Photodynamic therapy is a relatively new and promising treatment for actinic keratoses.
To determine the effectiveness of ALA-IPL in treating actinic keratoses as well as reversing the signs of aging.
A retrospective trial of 17 patients treated with ALA-IPL. Patients were evaluated for improvement of telangiectasias, blotchy pigment, fine wrinkles, coarseness of skin and number of actinic keratoses. All side effects were recorded.
68% of actinic keratoses resolved after one treatment. There was a 55% improvement in telangiectasias, a 48% improvement in pigmentary irregularities and a 25% improvement in coarseness of skin texture. There was minimal change in fine wrinkle appearance. Side effects were minimal including mild erythema and edema for 3-5 days on average. No infections were noted.
ALA-IPL treatment is effective in treating both actinic keratoses and signs of photodamage. In this study, we achieved significant improvement after just one treatment. ALA-IPL is a safe, effective way to treat both actinic keratoses and photodamage with little down time.
AuthorsDavid K Avram, Mitchel P Goldman
JournalJournal of drugs in dermatology : JDD (J Drugs Dermatol) 2004 Jan-Feb Vol. 3 Issue 1 Suppl Pg. S36-9 ISSN: 1545-9616 [Print] United States
PMID14964760 (Publication Type: Journal Article)
Chemical References
  • Aminolevulinic Acid
  • Adult
  • Aged
  • Aminolevulinic Acid (adverse effects, pharmacology, therapeutic use)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Photosensitivity Disorders (drug therapy, pathology)
  • Phototherapy (adverse effects, methods)
  • Retrospective Studies
  • Skin Aging (drug effects)

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