| Abstract | The flavonoid extract from Epimedium sagittatum (FES) has been found by us to be effective in preventing osteoporosis induced by ovariectomy in rats. In the present study, the effect of FES on the development of rat calvarial osteoblast-like (ROB) cells was investigated. No appreciable effect was observed when ROB cells were exposed to FES in vitro. However, serum isolated from rats administered FES orally was able to significantly stimulate the proliferation as well as the osteoblastic differentiation of ROB cells compared to serum from control rats. The results indicate that the serum of rats administered FES contains active metabolites ofFES that enhance the development of osteoblasts, while the original form of FES itself is inactive. |
| Authors | K M Chen, B F Ge, H P Ma, R L Zheng
(Affiliation: School of Life Sciences, Lanzhou University, Lanzhou, Gansu, People's Republic of China.)
|
| Journal | Die Pharmazie
(Pharmazie)
Vol. 59
Issue 1
Pg. 61-4
(Jan 2004)
ISSN: 0031-7144 Germany |
| PMID | 14964424
(Publication Type: Journal Article)
|
| Chemical References |
- Flavonoids
- Plant Extracts
- Osteocalcin
- Calcium
- Alkaline Phosphatase
|
| Topics |
- Alkaline Phosphatase
(metabolism)
- Animals
- Animals, Newborn
- Calcification, Physiologic
(drug effects)
- Calcium
(metabolism)
- Cell Differentiation
(drug effects)
- Cell Division
(drug effects)
- Cells, Cultured
- Epimedium
(chemistry)
- Flavonoids
(chemistry, pharmacology)
- Osteoblasts
(drug effects)
- Osteocalcin
(metabolism)
- Osteoporosis
(pathology)
- Plant Extracts
(chemistry, pharmacology)
- Rats
- Rats, Wistar
- Skull
(cytology, drug effects, growth & development)
|
