Results of this multicentric study have shown that by giving 10 g (10
tablets) of Master
Amino acid Pattern (MAP) as a substitute for
dietary proteins, once a day, to 114
overweight participants undergoing the American Nutrition Clinics/
Overweight Management Program (ANC/OMP), the participants'
nitrogen balance could be maintained in equilibrium with essentially no calories (MAP 1 g=0.04 kcal), thereby preserving the body's structural and functional
proteins, eliminating excessive water retention from the interstitial compartment, and preventing the sudden weight increase after study conclusion commonly known as the yo-yo effect. Study results have shown that the use of MAP, in conjunction with the ANC/OMP, has proven to be safe and effective by preventing those adverse effects associated with a negative
nitrogen balance, such as oversized or flabby tissue,
stretch marks, sagging of breast tissue, increased
hair loss, faded hair color, and fragile or brittle nails. Also preventing those anomalies commonly associated with
weight-loss diets, such as hunger, weakness,
headache caused by
ketosis,
constipation, or decreased libido, the use of MAP, in conjunction with the ANC/OMP, allowed for mean
weight loss of 1.4 kg (3 lb) per week.