HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Evaluation of the IRF-2 gene as a candidate for PSORS3.

Abstract
Type 1 interferon can trigger flares of psoriasis. Hypersensitivity to type 1 interferon signaling causes a psoriasis-like skin disease in mice deficient for the transcription factor interferon regulatory factor 2 (IRF2). The human IRF2 gene is located at a previously identified candidate psoriasis susceptibility locus on chromosome 4q (PSORS3 at D4S1535). Therefore, we tested association of psoriasis with IRF2. We generated a sample consisting of 157 families with a total of 521 individuals. Five novel microsatellite markers were developed and typed, and complemented with three known markers to yield a set of eight markers spaced within 600 kb around the IRF2 gene, three of which are located in the gene. We detected association of IRF2 with type 1 psoriasis at two markers in the IRF2 gene. Haplotype sharing analysis confirmed association of IRF2 with type 1 psoriasis (p=0.0017; pcorr=0.03). The 921G/A SNP in exon 9 was found to obliterate a predicted exon splice enhancer in an allele-specific manner. There was a suggestive increase of homozygosity for the splicing-deficient allele in type 1 psoriasis patients. Our data identify IRF2 as a potential susceptibility gene for psoriasis.
AuthorsJohn Foerster, Ilja Nolte, Susann Schweiger, Claudia Ehlert, Marcel Bruinenberg, Katja Spaar, Gerrit van der Steege, Marcel Mulder, Vera Kalscheuer, Bettina Moser, Zofia Kijas, Petra Seeman, Markward Ständer, Wolfram Sterry, Gerard te Meerman
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 122 Issue 1 Pg. 61-4 (Jan 2004) ISSN: 0022-202X [Print] United States
PMID14962090 (Publication Type: Journal Article)
Chemical References
  • DNA-Binding Proteins
  • IRF2 protein, human
  • Interferon Regulatory Factor-2
  • Repressor Proteins
  • Transcription Factors
Topics
  • DNA-Binding Proteins (genetics)
  • Exons
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Interferon Regulatory Factor-2
  • Microsatellite Repeats
  • Polymorphism, Single Nucleotide
  • Psoriasis (genetics)
  • RNA Splicing (genetics)
  • Repressor Proteins
  • Transcription Factors

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: