Studies on the antinephritic effects of plant components (6): antinephritic effects and mechanisms of phellodendrine (OB-5) on crescentic-type anti-GBM nephritis in rats (2).

Effects of phellodendrine (OB-5) on crescentic-type anti-GBM nephritis in rats and the cell number of the various leukocyte subpopulations in the glomeruli of the nephritic rats were investigated. OB-5 at 25, 50 and 100 mg/kg/day, p.o. prevented the urinary protein excretion by the 19th day after i.v.-injection of anti-GBM serum. In the OB-5-treated rats, plasma cholesterol and creatinine contents were lower than those of the control rats throughout the 40-day experimental period. Histopathological observations demonstrated that OB-5 inhibited the incidence of crescent formation, adhesion and fibrinoid necrosis in the glomeruli by the 41st day. OB-5 did not affect the plasma antibody titer against rabbit gamma globulin. The increases in total leukocytes, macrophages, cytotoxic/suppressor T cells, Ia positive cells, and IL-2 receptor positive cells in the glomeruli in OB-5, 100 mg/kg-treated rats as well as those of the animals treated with azathioprine or cyclosporin A were lower than those of the anti-GBM nephritic control. These results indicate that OB-5 was effective in crescentic-type anti-GBM nephritis and the antinephritic mechanisms of this agent may be due to its ability to inhibit the proliferation or the migration of macrophages and cytotoxic T lymphocytes in the glomeruli.
AuthorsT Hattori, K Furuta, K Hayashi, T Nagamatsu, M Ito, Y Suzuki
JournalJapanese journal of pharmacology (Jpn J Pharmacol) Vol. 60 Issue 3 Pg. 187-95 (Nov 1992) ISSN: 0021-5198 [Print] JAPAN
PMID1491511 (Publication Type: Journal Article)
Chemical References
  • Antibodies
  • Antibodies, Monoclonal
  • Quinolizines
  • phellodendrine
  • Cyclosporine
  • Cholesterol
  • Creatinine
  • Azathioprine
  • Animals
  • Antibodies (immunology)
  • Antibodies, Monoclonal (immunology)
  • Azathioprine (pharmacology)
  • Basement Membrane (immunology)
  • Cholesterol (blood)
  • Creatinine (blood)
  • Cyclosporine (pharmacology)
  • Glomerulonephritis (drug therapy, immunology, pathology)
  • Immunohistochemistry
  • Kidney Glomerulus (immunology)
  • Male
  • Proteinuria (urine)
  • Quinolizines (therapeutic use)
  • Rats
  • Rats, Sprague-Dawley

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