Abstract |
The pharmacokinetics of oral Alminoprofen, a nonsteroidal anti-inflammatory drug, were studied in five elderly patients with rheumatoid arthritis and spondylosis deformans after 200 mg (three times a day) repeated dose for 5 days. The pharmacokinetic parameters after oral administration of Alminoprofen were analyzed by the one-compartment open model method. The maximum plasma concentrations (Cmax) were 16.1 +/- 2.5 micrograms/ml, after dosing on day 1, 25.2 +/- 1.6 micrograms/ml on day 3 and 21.6 +/- 2.7 micrograms/ml on day 5. The maximum time (Tmax) were about 2 hours after the medication in al cases. The area under the curve in drug concentration in plasma versus time (AUC) were 58.5 +/- 6.3 micrograms hr/ml on day 1, 58.5 +/- 3.1 micrograms hr/ml on day 3 and 58.1 +/- 8.5 micrograms hr/ml on day 5. The biological half-lives (t1/2) were 2.45 +/- 0.35, 2.09 +/- 0.82 and 2.49 +/- 0.63 hours, after dosing on day 1, day 3 and day 5, respectively. The analysis of moment in pharmacokinetics revealed that the mean residence time (MRT) on day 1, day 3 and day 5 observed were 2.31 +/- 0.03, 2.15 +/- 0.09 and 2.15 +/- 0.07 hours, respectively. The variance residence times (VRT) observed were 0.95 +/- 0.05 hour2 on day 1, 0.88 +/- 0.09 hour2 on day 3 and 1.06 +/- 0.07 hour2 on day 5. The ratios of accumulation calculated were 1.16 +/- 0.05 in both the morning medication on day 3 day 5, and it therefore appears that the steady-state equilibrium is established within 3 days after commencement of dosage.(ABSTRACT TRUNCATED AT 250 WORDS)
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Authors | K Shin, M Takasaki, H Katsunuma, K Sato, T Shibuya, S Sato, H Hirayama |
Journal | Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics
(Nihon Ronen Igakkai Zasshi)
Vol. 29
Issue 11
Pg. 881-7
(Nov 1992)
ISSN: 0300-9173 [Print] Japan |
PMID | 1491485
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Propionates
- alminoprofen
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Topics |
- Administration, Oral
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, pharmacokinetics)
- Arthritis, Rheumatoid
(drug therapy, metabolism)
- Female
- Humans
- Male
- Propionates
(administration & dosage, pharmacokinetics)
- Spinal Osteophytosis
(drug therapy, metabolism)
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