Abstract |
Interleukin-6 (IL-6) has been shown to increase platelet counts in several animal models and to enhance megakaryocytopoiesis in vitro. In order to investigate the possible relationship between IL-6 and thrombocytosis, serum IL-6 levels in patients with platelet counts > or = 6 x 10(5)/microliters were measured using an IL-6-responsive bioassay. A cohort of healthy volunteers with normal platelet counts was used to establish a control mean serum IL-6 level [2.19 U/ml +/- 1.08 SD (range 0-5.5)]. Patients with primary thrombocytosis had a mean serum IL-6 level not significantly different from controls. In comparison, serum IL-6 levels of patients with reactive thrombocytosis were significantly greater than controls (38.3 U/ml +/- 94.6; range 0-933; P < 0.001). Although no significant correlation was observed between the degree of serum IL-6 elevation and the height of the platelet count in any individual, elevated serum IL-6 was highly correlated with reactive thrombocytosis.
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Authors | C W Hollen, J Henthorn, J A Koziol, S A Burstein |
Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 8
Issue 3
Pg. 235-41
(Oct 1992)
ISSN: 1042-8194 [Print] United States |
PMID | 1490150
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Hematopoiesis
- Humans
- Inflammation
(complications)
- Interleukin-6
(blood)
- Megakaryocytes
(pathology)
- Myeloproliferative Disorders
(blood, physiopathology)
- Neoplasms
(complications)
- Platelet Count
- Postoperative Complications
- Thrombocythemia, Essential
(blood, physiopathology)
- Thrombocytosis
(blood, etiology, physiopathology)
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