HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

In vitro activity of RU 29246, the active compound of the cephalosporin prodrug ester HR 916.

Abstract
The in vitro activity of RU 29246 was compared with those of other agents against 536 recent clinical isolates. The MICs of RU 29246 for 90% of members of the family Enterobacteriaceae tested (MIC90s) were less than 2 micrograms/ml except those for Morganella spp. (16 micrograms/ml) and Proteus spp. (8 micrograms/ml). RU 29246 was active against Staphylococcus aureus (MIC90, < or = 8 micrograms/ml) and against Staphylococcus saprophyticus and coagulase-negative staphylococci (MIC90s, < or = 2 micrograms/ml). Streptococci and Neisseria gonorrhoeae were highly susceptible to RU 29246, and the activity of the agent against isolates of Streptococcus pneumoniae (MIC90, < or = 0.5 micrograms/ml), Haemophilus influenzae (MIC90, < or = 2 micrograms/ml), and Moraxella catarrhalis (MIC90, < or = 2 micrograms/ml) was comparable to those of the other cephalosporins tested. RU 29246 was insusceptible to hydrolysis by the common plasmid-mediated beta-lactamases (TEM-1 and SHV-1). However, hydrolysis by the new extended-spectrum beta-lactamases (TEM-3, TEM-5, and TEM-9) was detected. Results of the study suggested that RU 29246 should be investigated clinically for use in the treatment of a wide range of infections.
AuthorsG Riess, J Andrews, D Thornber, R Wise
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 36 Issue 11 Pg. 2360-4 (Nov 1992) ISSN: 0066-4804 [Print] United States
PMID1489178 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Cephalosporins
  • HR 916
  • Prodrugs
  • RU 29246
Topics
  • Bacteroides fragilis (drug effects)
  • Cephalosporins (metabolism, pharmacology)
  • Enterobacteriaceae (drug effects)
  • Microbial Sensitivity Tests
  • Neisseria (drug effects)
  • Prodrugs (metabolism, pharmacology)
  • Staphylococcus aureus (drug effects)
  • Streptococcus agalactiae (drug effects)
  • Streptococcus pneumoniae (drug effects)
  • Streptococcus pyogenes (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: