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Photoallergic dermatitis from 8-methoxypsoralen.

Abstract
A 36 year old woman with psoriasis vulgaris developed generalized photoallergic dermatitis to 8-methoxypsoralen after 16 uneventful treatments with 8-methoxypsoralen und UVA (PUVA). The diagnosis of photoallergy was confirmed by re-exposure to oral 8-methoxypsoralen and total body UVA irradiation; phototests using topical and oral 8-methoxypsoralen with a high intensity monochromator or with a new high intensity light apparatus for the delivery of UVA; and histological studies. Photoallergy occurred only with UVA, but not with UVB or UVC. There was no photoallergy following trimethylpsoralen.
AuthorsG Plewig, C Hofmann, O Braun-Falco
JournalArchives of dermatological research (Arch Dermatol Res) Vol. 261 Issue 2 Pg. 201-11 (Apr 07 1978) ISSN: 0340-3696 [Print] Germany
PMID148873 (Publication Type: Journal Article)
Chemical References
  • Methoxsalen
Topics
  • Adult
  • Drug Eruptions (etiology, pathology)
  • Female
  • Humans
  • Methoxsalen (adverse effects)
  • Photochemotherapy (adverse effects)
  • Photosensitivity Disorders (chemically induced, pathology)
  • Psoriasis (drug therapy)
  • Ultraviolet Rays

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