[Hormone therapy using tamoxifen in unresectable carcinoma of the pancreas--preliminary study].

Abstract

In 1981 Greenway and co-authors reported the existence of estrogen receptor in tumor tissue of the pancreas. We have tried hormone therapy using tamoxifen in 4 of 11 patients with unresectable carcinoma of the pancreas in whom expandable metallic stents were inserted for the palliation of obstructive jaundice. The mean survival period in these 4 patients was 235 days, and 2 of them had a remarkably long survival of 321 and 463 days respectively. On the other hand, the mean survival was 128 days in 7 control patients. We therefore evaluated this new therapy with tamoxifen as effective in patients with unresectable carcinoma of the pancreas.

• Authors: S Morita, T Motohara, K Ogawa, T Horimi
• Journal: Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica (Nihon Igaku Hoshasen Gakkai Zasshi) Vol. 52 Issue 12 Pg. 1686-8 (Dec 25 1992) ISSN: 0048-0428 [Print] Japan
• PMID: 1488298 (Publication Type: English Abstract, Journal Article)

Chemical References

• Estrogens
• Tamoxifen

Topics

• Estrogens (physiology)
• Humans
• Neoplasms, Hormone-Dependent (drug therapy)
• Pancreatic Neoplasms (drug therapy)
• Tamoxifen (therapeutic use)