Determination of carcinogenic potency of alkytoxynol-741 (AP-741) by rat peritoneal cell cultures.

Abstract

The carcinogenic potency of AP-741 was tested in rats using the Nashed method of rat peritoneal cell short-term carcinogenic test. N-methyl-N-nitro-N'-nitrosoguanidian (MNNG) was used as positive control; saline and nonoxynol-9 (NP-9) were used as negative control. Two doses of AP-741 (4 mg/kg and 40 mg/kg equivalent to 4 and 40 times human doses) were tested. The result showed that no colonies of more than 9 cells were seen in the saline and NP-9 groups, and the two dose groups of AP-741. However, 12 +/- 8.3 colonies (9-29 cell/colony) and 4.5 +/- 4.2 colonies (30-300 cell/colony) were seen in the MNNG group. According to the Nashed criterion, we can say MNNG has potential carcinogenesis, while AP-741 does not have any potential carcinogenesis and its use as a vaginal contraceptive drug is safe.

• Authors: J Qin, C Wang, Q He, X Diao
• Journal: Contraception (Contraception) Vol. 46 Issue 4 Pg. 399-406 (Oct 1992) ISSN: 0010-7824 [Print] United States
• PMID: 1486778 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Spermatocidal Agents
• agent 741
• Polyethylene Glycols

Topics

• Animals
• Carcinogens (toxicity)
• Cell Division (drug effects)
• Cells, Cultured
• Dose-Response Relationship, Drug
• Female
• Polyethylene Glycols (adverse effects)
• Rats
• Rats, Sprague-Dawley
• Spermatocidal Agents (toxicity)