The treatment of Peyronie's disease with tamoxifen.

Abstract

This is a preliminary study of the treatment of 36 patients with Peyronie's disease who received tamoxifen 20 mg twice daily for 3 months. An improvement occurred in 16 of 20 patients with penile pain, in 11 of 31 patients with an erectile deformity and 12 of 35 patients had a plaque shrinkage of at least 1 cm. Some improvement occurred in 6 of the 8 patients with a histologically confirmed inflammatory infiltrate of the plaque but not in any of the 4 patients without an infiltrate. The inflammatory infiltrate was found in patients in whom the duration of the disease was less than 4 months.

• Authors: D J Ralph, M D Brooks, G F Bottazzo, J P Pryor
• Journal: British journal of urology (Br J Urol) Vol. 70 Issue 6 Pg. 648-51 (Dec 1992) ISSN: 0007-1331 [Print] England
• PMID: 1486392 (Publication Type: Journal Article)

Chemical References

• Tamoxifen

Topics

• Adult
• Aged
• Humans
• Male
• Middle Aged
• Penile Induration (drug therapy, pathology)
• Penis (pathology)
• Tamoxifen (therapeutic use)
• Time Factors