Abstract |
In a double-masked, randomised, controlled study the effectiveness and safety of 0.3% ofloxacin solution were compared with those of 0.3% gentamicin ophthalmic solution in treating external bacterial ocular infections. The clinical improvement rate for patients treated with ofloxacin was 98% (51/52) and 92% (48/52) for those treated with gentamicin. Microbiological improvement was achieved in 78% (40/51) of the ofloxacin patients, compared with 67% (35/52) of the gentamicin group. Ofloxacin treatment eradicated or controlled 85% (86/101) of the Gram positive and 89% (17/19) of the Gram negative organisms cultured, compared with 83% (103/124) and 78% (29/37), respectively, after gentamicin treatment. None of these differences were statistically significant. The incidence of adverse effects attributable to ofloxacin treatment (3.2%) was less than that reported for gentamicin (7.1%). Ofloxacin proved to be an effective, safe, and comfortable therapy for external bacterial ocular infection.
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Authors | A Gwon |
Journal | The British journal of ophthalmology
(Br J Ophthalmol)
Vol. 76
Issue 12
Pg. 714-8
(Dec 1992)
ISSN: 0007-1161 [Print] England |
PMID | 1486071
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Gentamicins
- Ophthalmic Solutions
- Ofloxacin
|
Topics |
- Administration, Topical
- Adult
- Aged
- Aged, 80 and over
- Blepharitis
(drug therapy)
- Conjunctivitis
(drug therapy)
- Eye Infections, Bacterial
(drug therapy)
- Female
- Gentamicins
(administration & dosage)
- Humans
- Male
- Middle Aged
- Ofloxacin
(administration & dosage)
- Ophthalmic Solutions
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