Solcoderm as alternative conservative treatment for acute anal fissure: a controlled clinical study.

Abstract	Acute anal fissure is a common malady that results in morbidity. If a patient is not responsive to conservative treatment, the current recommended treatments are either anal dilatation or lateral internal sphincterotomy. Both operations promise relatively good results, but the recurrence rates are about 16 per cent and 7 per cent, respectively. This fact, together with possible postoperative complications and costs, justifies trying conservative treatment before referring patients for surgery. The authors treated a study group of 25 patients with a topical application of Solcoderm. Another group of 25 patients concurrently treated with the usual conservative treatment served as the control group. Analysis of the early and late results proved Solcoderm to be simple to use, safe, without systemic side effects, cost-effective, and with statistically significant better outcome. Consequently, the authors believe that this method of treatment is justified in cases of acute and fissure and should be attempted before operation.
Authors	J Chen, M Michowitz, J B Bawnik
Journal	The American surgeon (Am Surg) Vol. 58 Issue 11 Pg. 705-9 (Nov 1992) ISSN: 0003-1348 [Print] United States
PMID	1485705 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References	Acetates Dermatologic Agents Lactates Nitrates Copper Acetic Acid
Topics	Acetates (administration & dosage, pharmacology, therapeutic use) Acetic Acid Acute Disease Administration, Topical Adult Aged Antineoplastic Combined Chemotherapy Protocols Comorbidity Copper (administration & dosage, pharmacology, therapeutic use) Cost-Benefit Analysis Dermatologic Agents (administration & dosage, pharmacology, therapeutic use) Female Fissure in Ano (diagnosis, drug therapy, physiopathology) Follow-Up Studies Humans Israel Lactates (administration & dosage, pharmacology, therapeutic use) Male Middle Aged Nitrates (administration & dosage, pharmacology, therapeutic use) Outpatient Clinics, Hospital Recurrence Referral and Consultation Treatment Outcome Wound Healing (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!